Nice and unified sound in the first 20 secs. I feel this song is a bit wet, but better to be too wet than too dry.
On your main synth around the 40 sec mark, try to tighten up the composition it seems a bit meandering, make sure you're 'saying something'. You don't have to make it cliche, just make sure it's really saying something.
On the other hand it works later on in the song, when you switch the instrument. Maybe it's just that synth, that doesn't fit that melody. Once the melody switches back to that synth it once again sounds a bit off, like it doesn't fully fit.
You have to be really careful with 'wandering' melodies and make sure there is the right composition around them for them to work.
I like your classical-esque lead around 1:50, your work reminds me a bit of my friends Draconum, (aka Genettic)
Anyway, nice song, keep at it, and experiment with changing up instruments.